Endocrine Abstracts

Purpose: The purpose of this study was to evaluate the relation gestational diabetes mellitus (GDM) and the thiol/disulfide balance, used as a marker of oxidative stress, by measuring that exchange using a novel technique.Material/Methods: Thirty one subjects diagnosed with GDM and 30 healthy pregnant women were included in the study. Thiol/disulfide homeostasis concentrations were measured by a newly developed method in this study. After native thiol, t...

Introduction: The purpose of this study was to evaluate the relation between menopausal women and the thiol/disulphide balance, used as a marker of oxidative stress, by measuring that exchange using a novel technique.Methods: Fourty five postmenopausal subject and 39 healthy participant were included in the study.Results: We found that in postmenopausal group, disulphide (P=0.04), disulphide/native thiol (P=0.004)...

Background: Thyroid hormones have been shown to be necessary for proper function of brown adipose tissue (BAT) and cold induced thermogenesis (CIT) in rodent models. In humans hyperthyroidism has been demonstrated to activate BAT and increase thermogenesis. However, the data on CIT in humans in the hypothyroid vs. the euthyroid state are limited and conflicting.Methods: This was a prospective observational study. We recruited 40 patients presenting to a ...

Purpose: The purpose of this study was to evaluate the relation polycystic ovarian syndome (PCOS) and the thiol/disulfide balance, used as a marker of oxidative stress, by measuring that exchange using a novel technique.Material/methods: Fourty nine subjects diagnosed with PCOS and 44 healthy were included in the study. Thiol/disulfide homeostasis concentrations were measured by a newly developed method. After native thiol, total thiol and disulfide leve...

Objective: Cushing’s syndrome (CS) is related to diabetes mellitus, dyslipidaemia, hypertension, and obesity, which lead to cardiovascular disease (CVD). CVD is the major cause of mortality and morbidity in CS. The aim of our study was to investigate CVD risk markers, such as asymmetric dimethylarginine (ADMA), lipoprotein-associated phospholipase A2 (Lp-PLA2), highly sensitive C-reactive protein (hsCRP), homocysteine, lipid levels, ankle-brachial index (ABI), and carotid...

Objective: Our purpose was to evaluate the impact of a transmission system on metabolic control of patients with diabetes.Research design and methods: This ongoing-prospective, randomized, comparative study included adult patients with type 1 (n=71) and type 2 diabetes (n=139). Consecutive patients were equally allocated into two groups. Both groups received routine care by the same health care professionals (HCPs) 3-monthly. TeleDiab g...

Background and aims: The history of GDM predisposes to cardiovascular disease (CVD) in the future. The aim of this study was to evaluate risk factors predicting the development of glucose intolerance and insulin resistance syndrome (IRS) in women with history of GDM in the future.Materials and methods: 55 women who had GDM 11±2 years before were enrolled into the study. After clinical examination 75 g OGTT and inflammatory markers(hsCRP, uric acid, ...

Introduction: Smoking harms women more than men and women seem to be less successful in quitting. Greater concerns about post-cessational weight in women and gender differences in craving and reward processing have been postulated as possible explanations. Our group recently showed that the GLP-1 analogue dulaglutide reduces post-cessational weight gain. We hypothesize that women compared to men might profit more from the weight-lowering effects of dulaglutide in terms of abst...

Introduction: Alcohol use disorder AUD causes high socio-economic costs and has a detrimental impact on health globally, being considered a key risk factor for non-communicable diseases. In Switzerland, four substances are currently approved for treatment of AUD, with varying effects. Taking into consideration the complex nature of the disease and the heterogeneity of affect patients, it becomes evident that there is need for new treatment targets. A body of preclinical studie...

Objective: Thiols are organic compounds that contain sulphydryl group (-SH) and have important role in preventing oxidative stress especially in cells. The aim of our study is to investigate the relationship between hypothyroidism due to HT and the thiol disulfide homeostasis, the effect of treatment on this homeostasis and to demonstrate the utility of thiol/disulphide homestasis as a marker for assessing the damage to functional group of proteins and the oxidative balance in...